Exposure of the U.S. Population to Acrylamide in the National Health and Nutrition Examination Survey 2003-2004

摘要

The lifelong exposure of the population to acrylamide has raised concerns about the chemical's possible health effects. Data on the extent of exposure to acrylamide and its primary metabolite glycidamide are needed to aid in the assessment of potential health effects. The aim of this study was to assess human exposure to acrylamide and glycidamide in the general U.S. population through the measurement of hemoglobin adducts of acrylamide (HbAA) and glycidamide (HbGA). HbAA and HbGA were measured in 7,166 subjects from the National Health and Nutrition Examination Survey. Stratified HbAA and HbGA data were reported by sex, age groups, race/ethnicity (Mexican Americans (MA), non-Hispanic blacks (NHB), non- Hispanic whites (NHW)), and smoking status based on serum cotinine levels. Covariate-adjusted geometric means for each demographic group were calculated using multiple regression analysis.