NTP Technical Report on the Toxicology and Carcinogenesis Study of Ethinyl Estradiol (CAS NO. 57-63-6) in Sprague-Dawley Rats (Feed Study)

摘要

Ethinyl estradiol is a potent synthetic estrogen widely usedin pharmaceutical preparations. Its high potency and wide-spread use led to its selection by the National ToxicologyProgram for inclusion in studies to examine endocrine disrupting compounds with estrogenic activity both becauseof its utility as a positive control to which weaker estrogenscan be compared and because of potential human developmental exposures resulting from unintentional continuation of the use of oral contraceptives containing ethinylestradiol during early pregnancy. The study protocol utilized Sprague-Dawley rats and was designed to evaluatethe effects of shortterm, multigenerational, and long-termexposures to doses of estrogenic agents that produce subtle reproductive tract lesions in developmentally exposedSprague-Dawley rat pups.