NIOSH Skin Notation (SK) Profile: Epichlorohydrin (CAS No. 106-89-8).

摘要

This Skin Notation Profile presents (1) brief summary of technical data associated with skin contact with epichlorohydrin and (2) the rationale behind the hazard-specific skin notation (SK) assignment for epichlorohydrin. The SK assignment is based on the scientific rationale and logic outlined in the Current Intelligence Bulletin (CIB) 61: A Strategy for Assigning New NIOSH Skin Notations [NIOSH 2009]. The summarized information and health hazard assessment are limited to an evaluation of the potential health effects of dermal exposure to epichlorohydrin. A literature search was conducted through July 2010 to identify information on epichlorohydrin, including but not limited to data relating to its toxicokinetics, acute toxicity, repeated-dose systemic toxicity, carcinogenicity, biological system/function-specific effects (including reproductive and developmental effects and immunotoxicity), irritation, and sensitization. Information was considered from studies of humans, animals, or appropriate modeling systems that are relevant to assessing the effects of dermal exposure to epichlorohydrin. Epichlorohydrin is potentially capable of causing numerous adverse health effects following skin contact. A critical review of available data has resulted in the following SK assignment for epichlorohydrin: SK: SYS-DIR (COR)-SEN. Table 1 provides an overview of the critical effects and data used to develop the SK assignment for epichlorohydrin.