Stability of Pyridine-2-Aldoxime Methiodide (2-PAM) 1.Mechanism of Breakdown in Aqueous Alkaline Solution

摘要

Pyridine-2-aldoxime methiodide (2-PAM, 2-formyl-l-methy1-pyridinium iodide oxime) has been found to be an effective chemical for overcoming the neuromuscular block that occurs in nerve gas poisoning. As part of a program leading to the development of a stable and effective therapeutic formulation of 2-PAM, the mechanism of the deterioration of 2-PAM in aqueous solutions of pH values ranging from 7 to 13 has been studied.