SERUM ENZYME CHANGES AFTER ADMINISTRATION OF NEPHROTOXIC DRUGS

摘要

Serum enzymes (lactic dehydrogenase, aldolase, and enolase) were measured after administration of the nephrotoxic compounds mercuric chloride, sodium tetrathionate, polymyxin B, and carbon tetrachloride. Renal function studies (RPF and GFR) were run before and after the compounds were given to check for kidney damage; this was found after sodium tetratmionate and carbon tetrachloride. Serum enzyme activity reached a maximum characteristic of each compound and its route of administration at the following times postinection: mercuric chloride, intravenously, 1 to 2 hours; sodium tetrathionate, intravenously, 12 to 24 hours; (carbon tetrachloride, orally, 24 hours; polymyxin B, intramuscularly, 12 to 24 hours. All of these compounds raised LPH and aldolase activities, but there was no change in enolase activity.nElectrophoretic separation of serum increased aldolase activity tenfold and LDH activity fivefold, peak activity being observed in the gamma-globulin area following damage by carbon tetrachloride or sodium tetrathio¬nate. After mercuric chloride a double peak occurred one in the gamma-globulin area and another higher peak in the alphaglobulin area.