RENAL RESPONSES TO POSITIVE ACCELERATION

摘要

The para-amino hippurate (PAH) clearances, creatinine clearances and urine flows of young male subjects exposed to positive acceleration have been studied. Exposures at 3 g for 10 minutes produced no consistent changes in the above parameters from control values. Longer exposures at 3 g produced a reduction of the para-amino hippurate (PAH) clearance in some subjects, no consistent changes in creatinine clearances, and significant reductions in urine flow following centrifugation. It is concluded that positive acceleration as used in the present experiments affects the kidney primarily through mechanisms involving a reduction of the thoracic blood volume.