GLOMERULAR FILTRATION AND RENAL PLASMA FLOW DURING HYPERTHERMIA

摘要

The factors that determine the direction and magnitude of the alteration in glomerular filtration rate (GFR) and renal plasma flew (RPF) in hyperthermia were studied. The investigation was conducted on anesthetized dogs, with creatinine clearance being used to measure GFR and para-aminohippuric acid (PAH) to measure RPF. The GFR in 12 mildly dehydrated dogs went from a control value of 68.4 ± 4.5 ml./minute at rectal temperature (RT) of 38.9° C. to a value of 25.1 ± 8.5 ml./minute at rectal temperature of 42.1° C, after 5 hours of exposure to heat. Final dehydration averaged —2 percent body weigh.