Preparation of Human Transplantation Antigens from Blood Leucocytes

摘要

Pretreatment of human recipients with transplantation antigens isolated from blood leucocytes may be associated with prolongations of survival of skin homografts obtained from the same donors. It may also induce accelerated or white graft rejection of transplants obtained from other sources. Injection of transplantation antigens pooled from a large number of donors has resulted in sharp decreases in survival times of skin grafts obtained from other unreleated individuals. Studies of the role of erythrocyte and leucocyte groups in human homograft reactions indicate that: (a) ABO group antigens play a significant role in conditioning the response of recipients to group specific skin grafts, (b) sensitization with transplantation antigens obtained from leucocyte group-incompatible sources induces in the recipients an accelerated rejection of grafts obtained from other donors selected on the basis of the same group incompatibilities. It is concluded from these studies that AB antigens of red blood cells and leucocyte group antigens are both active as transplantation antigens in man. The selection of donor-recipient combinations on the basis of erythrocyte and leucocyte group compatibility, coupled with the injection of large doses of transplantation antigens isolated from leucocytes, may provide a model for further attempts to facilitate or enhance the survival of tissue transplants in man. (Author)