Acute and Repeated Dose Toxicity Studies on Nsc 94100 Following Daily Oral Administration to Dogs and Monkeys and Acute Toxicity Following Oral Administration to Mice and Rats

摘要

Compound NSC 94100, D-Mannitol, 1,6-dibromo-1,6-dideoxy- was studied following daily oral administration in beagle dogs in dosages of 200 mg/kg x 6, 100 mg/kg x 5, 50 mg/kg x 10, 35 mg/kg x 12, 25 mg/kg x 14, and 13 mg/kg x 90, the dosages being administered in gelatin capsules and in Rhesus monkeys at daily dosages of 150 mg/kg x 8, 75 mg/kg x 8, 38 mg/kg x 9, 19 mg/kg x 21 and 57, and 10 mg/kg x 200. The drug was administered to the monkeys by gavage as a suspension in water. The tolerable dose in dogs was 13 mg/kg/day x 90 and the tolerable dose in the monkey was 10 mg/kg x 200. A single dose of 600 mg/kg P.O. was administered to a single dog. The oral LD50 was determined in mice and rats and range finding toxicity tests were done following I.P. administration in mice. (Author)