Study of Vaccines for Immunization Against Viral Respiratory Infections

摘要

Investigation in Navy and Marine recruits at San Diego, California was inconclusive regarding some spread of vaccine virus to cohorts. Analysis of Adenovirus type 4 related ARD occurring in placebo-treated groups lends credence to the possibility that they were the result of transmission of vaccine virus. In the absence of a distinguishing 'marker,' it is not possible to prove that the vaccine virus was transmitted to placebo-treated cohorts. In the first study of spread of Adenovirus type 4 vaccine virus in married couples, there was evidence of spread of virus between marital partners. In four couples, both partners had positive serologic response. In three of those with serologic response and in nine additional couples, there was evidence of spread by virus isolation. The serology and virus studies on a second study are incomplete, but available data thus far yields confirmation of spread between marital partners. Reinfection by oral vaccine virus occurred in four of six subjects in whom neutralizing antibody to Adenovirus type 4 persisted for one year after initial challenge. (Author)