The Effect of Chemical Structure and Surface Properties of Synthetic Polymers on the Coagulation of Blood

摘要

The adsorption, under flow conditions, of serum albumin to Silastic and polyethylene surfaces has been studied by infrared internal reflection spectroscopy. Infrared studies of sorption of plasma proteins by various cellulosics have also been made. These materials represent model hydrophilic surfaces. The results show that adsorption depends on protein molecular weight. Phospholipid suspensions formed by various dispersion techniques show a maximum in the amount adsorbed in laminar flow to polyethylene surfaces as a function of contact time. The adsorption of gamma-globulin to four neutral hydrophobic surfaces has been studied in the electron microscope. An electron microscope study of lecithin micelles on a carbon surface showed them to be circular particles (discs or spheres) with characteristic dimensions of 500 to 3000 A. The changes in activity of acid phosphatase and prothrombin-thrombin systems on adsorption to polymer surfaces were also investigated. Studies of platelet adherence to polymers in contact with whole blood have continued. Several members of a series of segmented polyurethanes have been synthesized. These are based on methylene bis(4-phenyl isocyanate), polypropylene glycol, or polytetramethylene glycol and various diamines. (Author)