NTP Technical Report on the Toxicology and Carcinogenesis Studies of Methyl trans-Styryl Ketone (CAS NO. 1896-62-4) in F344/N Rats and B6C3F1 Mice(Feed and Dermal Studies).

摘要

Methyl trans-styryl ketone is used as a synthetic fla-voring agent and a fragrance additive in food and per-sonal care products. Methyl trans-styryl ketone was nominated for study by the National Cancer Institute due to widespread human exposure as a flavoring and fragrance additive, positive results in the Ames/Salmonella assay and the mouse lymphoma L5178Y/tk+/- assay, and as a representative of the a,ss-unsaturated ketone chemical class. Male and female F344/N rats and B6C3F1 mice received methyl trans-styryl ketone (98.6% pure) in feed for 3 months and dermally for 3 months or 2 years. Genetic toxicology studies were conducted in Salmonella typhimurium, Escherichia coli, and mouse peripheral blood erythro-cytes. Two-year studies were conducted to provide data for assessment of possible toxicity due to exposure to methyl trans-styryl ketone. The dermal route was cho-sen since this is the route for highest human exposure and due to studies demonstrating systemic exposure following dermal application to methyl trans-styryl ketone.