N-Dealkylation of Tertiary Amines

摘要

N-Dealkylation reactions are important in synthetic organic chemistry. These are also extensively employed in the structure determination of the unknown compounds containing nitrogen. N-Dealkylation is largely encountered in the biological systems also. The aim of the work is to obtain as much information as possible from chemical literature to review the progress made in N-Dealkylation reaction mechanisms. N-Dealkylation of tertiary amines has been studied extensively by reaction with a variety of oxidizing agents. The oxidation of amines is dependent on the reaction conditions, the oxidizing agent and the structure of the amine. However, there is little correlation between reaction intermediates and products formed and many oxidants yield more than one product.