Single-Dose Toxicity of 3-Tritylthio-L-Alanine Clinical Formulation (NSC 83265),Administered in Dogs by the Intravenous Route.

摘要

The S-substituted cysteine derivative, 3-tritylthio-L-alanine (NSC 83265),was administered to young adult beagle dogs in a single intravenous dose of 25, 50, 100or 200mg/kg. Death occurred only at the highest dose level but was delayed in the female,occurring Day 4. Marked toxic signs were noted in the dogs given 100mb/kg: emesis,incontinence, lethargy and semi-responsiveness. At the lower dose levels signs of toxicity were generally minimal. At dose levels >or = 100mg/kg the drug was leukotoxic and produced some kidney involvement indicated by elevated BUN levels. Liver damage,manifested by very markedly elevated SGPT, SGOT and alkaline phosphatase levels,was observed at doses of 50mg/kg and higher. This liver damage appeared to be readily reversible as liver micropathology was minimal except in the female sacrificed one week after a dose of 100mg/kg. On the basis of these findings the highest non-toxic dose of NSC 83265was about 25mg/kg.