Evaluation of Carcinogenic, Teratogenic,and Mutagenic Activities of Selected Pesticides and Industrial Chemicals. Volume II. Teratogenic Study in Mice and Rats.

摘要

Forty-eight compounds having uses such as insecticides,herbicides,fungicides were given to pregnant mice and rats to evaluate their effects on implantation,fetal mortality,wt. and development,placental wt.,amniotic fluid volume,maternal wt.,and maternal liver/body wt. These compounds were suspended in 50% solution of honey in water. Subcutaneous injections were made into the nape of neck. These compounds were dissolved in DMSO or saline. All mice were sacrified on the 18th day of gestation. In the postnatal study,neonates were examined at birth,at 8days,and then sacrificed. Twenty-five fetal anomalies were seen in not more than four instances each in test mice. Renal agenesis,an exception,was seen 30times (28times in BL6mice given pent (PCNB) p.o.). PCNB and 2,4,5-trichloro-phenoxyacetic acid produced serious anatomic effects and were categorized probably dangerous. Significant increase in maternal and fetal/body liver wt. was observed in every strain of mice and rats at all dose levels after administration of 2,4,5-T,as well as excessive fetal abnormality and mortality.