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Study of Chronic Toxicity of Various Classes of Cancer Chemotherapeutic Agents (Report on NSC 77213, Procarbazine Hydrochloride).

机译：各类癌症化疗药物的慢性毒性研究（NsC 77213，盐酸丙卡巴肼的报道）。

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摘要

Daily oral administration of 18.75mg/sq m Procarbazine hydrochloride for 28days produces a delayed toxic response in beagles. Signs of toxicity included leukopenia and a reduction in red blood cell and platelet counts. One of two dogs which receive half this dose showed a leukopenia. Daily administration of 4.70mg/sq m had no effect on circulating blood cells.

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作者
henry,mary c.;
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年度 1973
页码 78p*
总页数 78
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
antineoplastic agents; toxicology; drugs; toxicology; malignant neoplasms; drugsbioassay; dogs; dosage; dose rate; hematology; leukopenia; erythrocytes; platelets;

机译：抗肿瘤药;毒理学;药物;毒理学;恶性肿瘤;药物生物测定;犬;剂量;剂量率;血液学;白细胞减少症;红细胞;血小板;

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2. Synthesis and characterization of Cu(II)-based anticancer chemotherapeutic agent targeting topoisomerase Iα: In vitro DNA binding, pBR322 cleavage, molecular docking studies and cytotoxicity against human cancer cell lines [J] . TabassumS., ZakiM., AfzalM., European Journal of Medicinal Chemistry: Chimie Therapeutique . 2014,第Null期

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8. Study of Chronic Toxicity of Various Classes of Cancer Chemotherapeutic Agents. Serial Studies of Serum Enzymes in Drug-Induced Hepatotoxicity in Dogs;NSC-79037 (chloroethylcyclohexyl-nitrosourcea) and NSC-406021 (ar abinosyl-6-mercaptopurine). [R] . henry,mary c. marlow,marilyn 1972

机译：各类癌症化疗药物慢性毒性研究。药物诱导的犬肝毒性中血清酶的系列研究; NsC-79037（氯乙基环己基 - 亚硝基鎓）和NsC-406021（ar abososyl-6-mercaptopurine）。

Study of Chronic Toxicity of Various Classes of Cancer Chemotherapeutic Agents (Report on NSC 77213, Procarbazine Hydrochloride).

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