Adherence of Blood Components to Artificial Kidney Membranes. Effects of Dialysance of Low and Middle Molecular Weight Solutes.

摘要

Effects of the adherence of blood components to dialyzer membranes were assessed in coils and hollow fiber kidneys. Dialysances of multiple solutes were measured using an aqueous perfusate at 100ml/min single pass before and after in vitro perfusion of artificial kidneys with whole blood. Similar studies were also performed before and after clinical dialyses with various coils and hollow fiber dialyzers. Extensive coating of membranes was present and studied morphologically in all dialyzers. Irreversible detrimental changes occurred in all HFK and reuse was not feasible. Coils could be reused up to six times as long as air rinsing of blood from the coils was not employed with no deterioration in dialysance values.