Respiratory Insufficiency: Pathophysiology Related to Implantation of Circulatory Support Systems.

摘要

The normal respiratory mechanics for the calf have been determined utilizing an analog/hybrid computer. Techniques for studying the awake, unanesthetized calf and mechanically ventilated calf have been developed. A volume respirator (Ohio 560) was shown to affect the pressure-related parameters of respiratory mechanics resulting in decreased compliance and increased work and resistance. In addition,gas flow and tidal volume predictably affect these parameters. Preliminary investigations have demonstrated: (1) The effects of open mask anesthesia,chest wall compression and phencyclidine hydrochloride on respiratory mechanics in the calf; (2) the intraoperative effects of abdominal left ventricular assist device implantation on respiratory mechanics;and (3) the postoperative effects of abdominal left ventricular assist device implantation on respiratory mechanics.