Metabolism of Carbamate Insecticides.

摘要

The metabolic fate of aldicarb,carbaryl,and carbofuran was investigated in a variety of biological systems. In addition,the effects of other insecticides and certain monoamine oxidase inhibitors on carbaryl metabolism in rats was studied. The fate of 3-hydroxy carbofuran,its glucoside and glucuronide,and naphthyl glucoside in rats was determined. Using 1-naphthol as a model compound,in vitro methods were developed to study mechanisms of glycosylation in insects and mammals. The glucosides of 4-and 5-hydroxy carbaryl were prepared chemically and their acute toxicity to mice compared to the aglycones. Results of these studies showed that carbamate insecticides are metabolized initially by hydrolytic-and oxidative-type reactions and the resulting products are then almost totally conjugated. These conjugated products constitute the majority of the terminal residues of carbamates in both animals and plants.