Toxicity Studies on NSC 4728m 1, 3, 4-Thiadiazole, 2-Amino-in Mice, Beagle Dogs,and Rhesus Monkeys,

摘要

NSC 4728, 1,3,4-Thiadiazole, 2-amino-,is approximately 7-8times more toxic to mice treated with single intravenous doses than to mice treated with single oral doses indicating that the compound is either poorly absorbed from the gastrointestinal tract or partially detoxified during absorption. The majority of deaths were acute. Histopathology in the mouse was noted in the liver,kidneys,spleen and rarely the lungs. Toxic signs noted in both dogs and monkeys included weight loss, emaciation,anorexia,rectal hemorrhage, salivation and hypothermia. The dogs and monkeys showed a mild decrease in erythroid elements,but at the lethal doses the dogs showed a preterminal hemoconcentration, a decrease in WBC with a shift to the left in the differential,biochemical evidence of hepatotoxicity and nephrotoxicity including albuminuria and ketonuria (monkeys only). In both dogs and monkeys histopathology was noted in the liver, G.I. tract,lung and site of injection.