Vinyl Acetate/Crotonic Acid Polyelectrolyte Hydrogel Coatings for Biomedical Applications.

摘要

Poly(vinyl acetate-co-2% crotonic acid) 60% sodium ionomer continues to be a promising hemocompatible material. Vena cava implant results on samples graft coated from monomers using Cobalt-60radiation techniques are essentially equivalent to results on the preformed hydrogel materials which were attached to mechanically supporting substrates using high doses of Van de Graaff radiation. The characteristic low water content of radiation grafted coatings have significantly increased by the use of very low radiation doses. Furthermore,varying monomer concentration and type of solvent provides a convenient method for control of coating parameters. Thus,at a dose level of 0.1Mrad in an aqueous emulsion system,hydrogel coatings with a thickness of 16microns and equilibrium water uptake values of 56% were produced. Renal embolus test results on these hydrogel coatings are encouraging.