Trace Element Abnormalities in Chronic Uremia.

摘要

The goals of the first six months of this contract were to standardize procedures and to verify the accuracy of determinations on a normal control population. In particular,it was necessary to check out all water sources,solutions,containers,instruments for possible trace element contamination. It was also desirable to develop a sample processing procedure that was applicable for both emission spectroscopy and atomic absorption. As the standardized procedure for emission spectroscopy has been to use freeze-dried samples,the atomic absorption techniques were modified so as to use the same samples. During the first six months of this contract,we have attempted to standardize our techniques for collection of samples and processing for analysis by both emission spectroscopy and atomic absorption. Samples of hair, RBC,plasma and 24-hour urine were examined by emission spectroscopy for Na, D,Ca, P,Mg,Cd,Zn,Cu,Pb,Fe,Mn,Al,Si, B,Sn,Co,Ni,Mo,Ti,Cr,Sr,Ba,Li,Ag, V,Be. The following elements were examined by atomic absorption:Hg,Pb,Cu,Cd,As,Mn,Cr. The data are currently being processed by computer and will be reviewed shortly.