Interactions of Natural and Chemically Modified Biopolymers with Blood.

摘要

The events which occur when platelets are brought into contact with collagen of various origins and in various states of physical assembly are being studied as models for the requirements for platelet activation in general. The various stages through which activation passes -adhesion,release and aggregation are being separately considered,as is the effect of plasma proteins in influencing the activation. It has been shown that while tropocollagen is unable to stimulate aggregation,binding between tropocollagen and platelets does occur. The individually dispersed alpha-chains,however,are inactive. The presence or absence of plasma proteins influences the extent of the interaction. The effectiveness of the protein covered surface was determined by competitive adsorption of the different protein components. Platelet adhesion to different protein layers adsorbed at the air/water interface was also considered.