Biological Transfer of Plutonium via in vivo Labeled Goat's Milk.

摘要

The long physical and biological half-life and high relative toxicity have dictated that considerable effort be devoted to quantifying plutonium transport through the various trophic levels. Despite the fact that biological transport of plutonium has been studied for many years,quantitative values for its transfer to milk,and its subsequent uptake by suckling animals have not been established. Three lactating goats were given intravenous injections of citrate-buffered plutonium nitrate at a rate of 75 microcuries per animal per day for three consecutive days. In all three goats approximately one percent of the total plutonium dose was transferred to the milk by the fifth post-treatment day. Plutonium retained by the tissues was deposited primarily in the liver and bone. In vitro plutonium-labeled milk was also fed to groups of rats and juvenile goats. Tissue concentrations of plutonium from juvenile goats which had received either in vivo or in vitro labeled milk were somewhat variable. Due possibly to this,within group variability and the small number of animals per group (two) there were no clearly discernible differences between treatments. The only comparison point to show a consistent trend was the observation that,as expected,juvenile rats retained more of the ingested dose than the adult animals.