Evaluation of Selected Pesticides as Chemical Mutagens 'In vitro'and 'In vivo'Studies,

摘要

Twenty pesticides were studied for mutagenic activity by several in vitro and in vivo test procedures. The pesticides reviewed were: monocrotophos, bromacil, cacodylic acid,captan, chlorpyrifos, dinoseb, DSMA, fenthion, folpet, azinphos-methyl,malathion, methomyl, monuron, MSMA,parathion,parathion-methyl, quintozene (PCNB), phorate, simazine,and trifluralin. Ten of the twenty compounds were evaluated in vivo by the mouse dominant lethal test. All twenty compounds were tested in vitro. None of the ten compounds tested in the mouse produced a dominant lethal response. Ten of the twenty compounds were mutagenic in one or more in vitro assays. Two were mutagenic in all of the in vitro assays:captan and folpet.