Vena Cava Ring Tests of Biomaterials in Dogs.

摘要

Canine vena cava implant tests for thrombogenicity were performed on materials. The tests were performed according to a formal protocol appended to this report. Among valid tests, 38% of the specimens produced little or no attached thrombus or thromboembolic complications after two weeks'implantation. Two sets of acetal resin control specimens showed widely different results (28% versus 65% with little or no thrombus) apparently due to differences in surface texture. Certain polyetherurethane coatings were found to improve the performance of the more thrombogenic of the acetal resin substrates. Shallow markings were found to render polycarbonate surfaces more thrombogenic. Other materials tested included carbon coatings,glow discharge polymers,heparin complexes,fluorinated ethylcellulose and hydrogels. Other work included in vitro testing of an ultrasonic probe for monitoring thrombus formation.