Cutaneous Irritation in the Topical Application of Azarabine NSC-67239to New Zealand White Rabbits.

摘要

The skin irritation potential of topically applied Azarabine NSC-67239on New Zealand white rabbits was evaluated utilizing the method of Draize. Histologic studies of selected tissues including skin test sites were performed. Topically applied Azarabine at concentrations of 1, 3,and 9percent produced no skin irritation. Histopathologic examination of the skin test sites confirmed that the test compound was not an irritant. No tissue damage was found in the kidney,spleen,liver,large or small intestine,bone,bone marrow,and ovaries or testes of the test animals that could be attributed to Azarabine treatment. It was concluded that Azarabine is not a skin irritant and does not produce acute organ toxicity in rabbits at concentrations of 9% or less when topically applied.