Criteria for a Recommended Standard: Occupational Exposure to o-Tolidine

摘要

O-Tolidine is widely used in the dye industry. It is also used in analytical chemistry procedures, including tests for chlorine in water, and in medical laboratory tests for sugar or occult blood. The biologic dye, trypan blue, contains the o-tolidine moiety. Animals exposed to o-tolidine have developed cancers at various sites, and results of bacterial tests indicate that o-tolidine may be mutagenic. Damage to mammalian DNA metabolism has also been reported. o-Tolidine is readily absorbed through the skin, and nasal irritation has been reported in humans exposed to it.