首页> 美国政府科技报告 >Acute Cardiovascular Effects of 3-Deazauridine (NSC-126849) Following Continuous Intravenous Infusion to Anesthetized Beaglehounds.
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Acute Cardiovascular Effects of 3-Deazauridine (NSC-126849) Following Continuous Intravenous Infusion to Anesthetized Beaglehounds.

机译:连续静脉输注麻醉Beaglehounds后3-脱氮尿嘧啶(NsC-126849)的急性心血管效应。

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Healthy,anesthetized beaglehounds were instrumented to monitor various cardiovascular parameters and their responses to doses of 1000, 2000,or 3000mg/kg (20000, 40000or 60000mg/sq. m.). Compound was given intravenously over an interval varying between approximately 20and 60minutes,and recordings were obtained during 2control periods and at 5, 20, 40and 60minutes after termination of infusion. All dogs survived the 60minute surveillance and no dog manifested serious derangement of parameters monitored. A single dog receiving the highest dose developed a rather precipitous fall in cardiac output by the 60th minute after infusion;otherwise only slight and clinically insignificant alterations in pressures and vascular resistance were observed. QRS duration and QT interval of the electrocardiogram prolonged in dogs receiving the highest and intermediate doses of this compound. This negative dromotropism mimics the effects of quinidine,and should be investigated further if this agent has potential for its antineoplastic qualities.

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