首页> 美国政府科技报告 >Towards an Artificial Liver Support, Detoxifying Enzymes Bound to Artificial Carriers for an Extracorporeal Application. Proceedings of the International Conference on Bioengineering Held at Cape Town, April, 1977
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Towards an Artificial Liver Support, Detoxifying Enzymes Bound to Artificial Carriers for an Extracorporeal Application. Proceedings of the International Conference on Bioengineering Held at Cape Town, April, 1977

机译:朝向人工肝支持,解毒结合人工载体的酶用于体外应用。生物工程国际会议论文集于1977年4月在开普敦召开

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摘要

In hepatic failure enzymes of detoxification in the liver are greatly reduced. The reduction of detoxification capacity results in an accumulation of toxins in the blood. These toxins inhibit many enzymes of liver and brain metabolism. Elimination of endogenous and exogenous toxins from the blood can be achieved in vitro and in vivo by use of sorbents. Charcoal is a potent substance to remove most of the toxins occuring in hepatic failure. However charcoal removes not only toxins but a large number of vital substances. Most hormones will be removed from the circulation by charcoal which has a negative effect on the state of the disease. Elimination of toxins can be achieved without loss of vital substances from the blood by use of highly specific carrier bound microsomal enzymes UDP-glucuronyltransferase, cytochrome-P-45o and NADPH-cytochrome-P-45o reductase.

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