Evaluation of Fluoropolymer Membranes in Oxygenators.

摘要

Development of a novel, thromboresistant biomaterial,fluorinated ethylcellulose (FEC),for use in membrane oxygenators was continued. Thin film composite membranes of FEC on Celgard microporous polypropylene film were fabricated in quantity under clean room conditions. Techniques were developed for fabrication of high performance spiral-coil membrane oxygenators,and initial tests were performed using lambs as the experimental animal. Oxygen-to-blood transfer rates up to 50ml/min at 1000ml/min blood flow through 0.8-square-meter devices were achieved under specific operating conditions. Additional studies on the blood compatibility of FEC further confirmed its high thromboresistance,very low hemolysis rate,and low level of interaction with blood platelets.