Microbial Mutagenesis Testing of Substances; Compound Report: F76-042, Ascorbyl palmitate

摘要

SRI International examined an FDA compound identified as F76-042. This compound was tested in the Ames Salmonella/microsome assay for induction of reverse mutation in Salmonella typhimurium strains TA1535, TA1537, TA1538, TA98, and TA100 and in Escherichia coli WP2 (uvrA). Each assay was performed in the presence and in the absence of a rat liver homogenate metabolic activation system. Toxicity, at a dose of 3333.3 microg/plate and above, was observed with TA1538, TA98, and TA100, with and without metabolic activation. Compound F76-042 did not appear to be mutagenic in these assays.