Diosgenin and Other Steroid Drug Precursors

摘要

The monograph gives a comprehensive and up-to-date account of the steroid drug precursors, with special reference to India and with emphasis on diosgenin. The monograph is divided into six chapters: INTRODUCTION--A fascinating account of developments in the steroid field and present trends; SOURCES OF DIOSGENIN--dioscoreas and other genera with their cultivation, economics, and tissue culture techniques; EXTRACTION AND ASSAY PROCEDURES OF DIOSGENIN--extraction methods with techno-economic data, and detailed assay procedures with their merits and demerits; DIOSGENIN CONVERSION TO STEROID DRUGS AND USES--16-DPA and product pattern with intermediates and yields, conversion to steroid drugs, microbiological transformations and uses; STEROID DRUG PRECURSORS OTHER THAN DIOSGENIN--solasodine hecogenin, sterols, bile acids, etc. their sources, conversions, future prospects; and PRODUCTION, REQUIREMENTS AND TRADE--production and demand of the precursors in India and the world, trends, competition from total synthesis and prostaglandins.