Rabbit Response to the Administration of Different Doses of Adriamycin

摘要

Adriamycin (NSC No. 123127), administered at 0.5, 1.0 or 1.5 mg/kg of body weight/week for twelve weeks, induced pathologic changes that increased with the dose. Weight loss was evident in rabbits receiving 0.5 mg/kg of body weight/week, but clinical signs, bio-chemical changes and microscopic examination of the heart, kidneys and bone marrows were similar to control animals. Rabbits receiving 1.0 mg/kg of body weight/week had a decreased survival, significant weight loss, biochemical alterations and chronic microscopic changes in the heart and kidneys. Rabbits treated with 1.5 mg/kg of body weight/week had the shortest survival of all grooups tested, with prominent weight loss and moderate to severe cellular deterioration in the myocardium and kidneys. Increasing ADR dose beyond 0.5 mg/kg of body weight/week produces marked renal and cardiac toxicosis, decreased animal survival time and markedly alters several hematological and enzyme parameters.