Intravenous Elimination and Percutaneous Absorption of Topically Applied Mercaptopurine-14C (NSC-755) in Yorkshire White Pigs.

摘要

The distribution and elimination of intravenously administered Mercaptopurine-14C (NSC-755) was studied in female, weanling, Yorkshire white pigs. Over one-half the radioactivity was eliminated in the urine in the first six hours. After 96hours (4days),an average of 80% was eliminated in the urine. This elimination percentage was then used to determine the amount of Mercaptopurine-14C absorbed after topical application. Among the whole organs sampled,kidney and liver had the highest specific activities of radioactivity. A blood-brain barrier appears to exist. Bone marrow had the highest specific activity level of the random tissues sampled. The absorption of Mercaptopurine-14C after topical application was minimal with approximately 1.51% of the applied dose being absorbed at the end of 192hours (8days). Significant levels of radioactivity were also detected in skin surrounding the site of application.