Interaction of Natural and Chemically Modified Aortic Tissue Proteins with Blood

摘要

The overall goal of this project is the evaluation of the thrombogenicity of aortic subendothelial connective tissue components. The major accomplishments achieved in this contract year include: (1) Completion of studies of the thrombogenicity of four types of polyurethanes, which confirmed major differences in platelet consumption induced by those polymers. (2) Further studies of platelet loss induced by injection of collagen into baboons. (3) Platelet consumption by immobilized collagen on shunts was found to depend on the collagen immobilization solvent, confirming previous results. (4) The adhesion of platelets to collagen immobilized on shunts was studied after brief exposure to flowing baboon blood and found to be very extensive and rapid. (5) New preparations of aortic collagen type I and III and anterior lens capsule type IV collagen were made and characterized. (6) A new molding apparatus for forming gels on the lumen of shunts was built.