Summarization of Recent Literature Pertaining to an Occupational Health Standard for Epichlorohydrin

摘要

The report summarizes pertinent information about epichlorohydrin in the areas of human and animal toxicology, analytical and sampling methods, work practices, and engineering controls. Published and unpublished research results appearing since preparation of the criteria document were considered, but only those results that may affect the recommended standard are included. In addition, this report notes deficiencies in present knowledge concerning effects of exposure to epichlorohydrin and outlines research designed to fill those gaps. This literature summary supplements but does not replace the extensive review in the NIOSH criteria document, which contained comprehensive surveys of all the literature available when the document was prepared, as well as recommendations for an occupational health standard. Although this report does not recommend exposure limits, work practices, or analytical methods, it provides information that will assist NIOSH in determining if there is sufficient new information to consider revising the recommended standard for epichlorohydrin.