Behavioral Effects of Moderate Lead Exposure in Children and Animal Models. Part 2: Animal Studies

摘要

It is apparent that high-level lead exposure can have serious effects on the intellectual and behavioral development of young children. Furthermore, substantial numbers of children are at risk for lead exposure. However, current concerns revolve more around low-level chronic exposure than around high-level lead poisoning. Of particular concern are issues of quantification of behavioral toxicity, dose-response parameters associated with toxicity, and critical periods of exposure; i.e. what types of behavioral of intellectual deficits occur at what levels of lead exposure during various stages of development. The present review attempts to organize the very large human and animal behavioral literature which has evolved during the past 10 to 15 years.