NTP Technical Report on the Toxicology and Carcinogenesis Studies of Trimethylolpropane Triacrylate (Technical Grade) (CAS NO. 15625-89-5) in F344/N Rats and B6C3F1/N Mice (Dermal Studies).

摘要

Trimethylolpropane triacrylate is a multifunctional monomer with a wide range of industrial applications. It is used in the production of ultraviolet-curable inks, electron beam irradiation-curable coatings, and polymers and resins; as a component of photopolymer and flexographic printing plates and photoresists; and as an ingredient in acrylic glues, adhesives, and anaerobic sealants. Additionally, trimethylolpropane triacrylate is used in paper and wood impregnates, wire and cable extrusion, polymer-impregnated concrete, and polymer concrete structural composites. Trimethylolpropane triacrylate was nominated by the National Cancer Institute for study due to its high production volume and use, the potential for human exposure, and the lack of adequate chronic toxicity and carcinogenicity data. Male and female F344/N rats and B6C3F1/N mice were administered technical grade trimethylolpropane triacrylate (greater than 78% pure) in acetone dermally for up to 2 years. Genetic toxicology studies were conducted in Salmonella typhimurium and Escherichia coli.