Movement of Mercury in Rat Submaxillary Slices

摘要

The movement of HgCl2 was studied in slices of rat submaxillary gland. A steady-state distribution was reached within 60 min. N2 or metabolic inhibitors failed to decrease tissue uptake. Increasing the concentration of Hg2+ produced a corresponding increase in tissue metal. Decreasing the incubation temperature decreased uptake. Cd2+ and Fe2+ decreased uptake but Zn2+, Cu2+, and Fe3+ were without effect. Efflux experiments indicated a firm binding of Hg2+. The data suggest a passive uptake for Hg2+ with unsaturable, temperature-sensitive binding sites in the interior of the cell.