Carcinogenicity and Metabolism of Azo Dyes, Especially Those Derived from Benzidine

摘要

Studies on the sites of carcinogenic action of benzidine (92875) in man and experimental animals, benzidine metabolism, azo compounds metabolism, and the epidemiological experience of industries using azo dyestuffs are reviewed. Industrial hygiene surveys to monitor the environment of workers exposed to azo dyes, monitor urinary excretions of aromatic amines and benzidine of those workers, and evaluate the effects of exposure to and the metabolism of azo dyes are described. The author concludes that benzidine derived dyes are potential carcinogens and recommends that other safe dyes be substituted for these dyes when possible.