Mutagenesis and Morphological Transformation of Mammalian Cells by a Non-Bay-Region Polycyclic Cyclopenta(cd)pyrene and Its 3,4-Oxide1

摘要

Cyclopenta(cd)Pyrene, a constituent of environmental emissions, has been found to mutate and transform mammalian cells in culture. Cyclopenta(cd)pyrene 3,4-oxide, a presumed metabolite, was found to a be direct-acting mutagen and to transform mammalian cells. These results suggest that cyclopenta(cd)pyrene 3,4-oxide may be an ultimate mutagenic form of the parent hydrocarbon.