A Study to Determine the Efficacy and Reactivity of Influenza Vaccine in Patients with Cystic Fibrosis and in Other High Risk Groups

摘要

A five year study was conducted on the reactogenicity and immunogenicity of split product (SP) and whole virus (WV) influenza virus vaccines in high risk children. Studies characterized fundamental differences between the two types of vaccines relative to immunological responses and reaction to vaccine administration. Studies include results obtained from 1976-77 National Influenza Immunization Trials, trials conducted in immunosuppressed in children with malignant disease, one high dose SP vaccine, 78-79 trials, immunizing adults with chronic bronchitis and the new Triton x-100 SP vaccine in 1979-80.