Development and Evaluation of a Long-Term Low Profile Intracorporeal (Abdominal) Left Ventricular Assist Device (THI E-Type ALVAD) Fascicle I

摘要

This comprehensive (two fascicle) technical report describes and details the progress made in the development and evaluation of a long-term low profile intracorporeal (abdominal) left ventricular assist device (THI E-Type ALVAD). Fascicle I describes the cumulative design and development of the THI E-type ALVAD and its components. It includes integration of the E-type ALVAD with electrical energy converters; in-vitro analyses of integrated systems; in-vivo hemodynamic evaluations in calves; THI E-type ALVAD feasibility studies and ex-vivo pseudoneointimal analyses. Fascicle II includes relevant correspondence, references (mechanical circulatory assistance) and selected THI E-type ALVAD publications.