Intravenous Elimination and Percutaneous Absorption of Topically Applied Thiotepa-14C in Yorkshire White Pigs

摘要

The distribution and elimination of intravenously administered Thiotepa - 14C (NSC 6396) was studied in female, weanling Yorkshire White Pigs. After 7 days an average of 53.88% was excreted via the urine and 4.76% via the feces. The urinary elimination percentage was then used to determine the amount of Thiotepa - 14C absorbed after topical application. Among the whole organs sampled following intravenous administration, liver, adrenals and kidney had the highest specific activities of radioactivity. Intestine had the highest specific activity level of the random tissues sampled. 9.67% of a topically applied dose of Thiotepa -14C was absorbed at the end of 7 days.