TSCA Chemical Assessment Series. Assessment of Testing Needs: Chlorinated Benzenes. Support Document for Proposed Health Effects Test Rule, Toxic Substances Control Act, Section 4

摘要

Since chlorobenzenes are used as chemical intermediates and for other industrial purposes as well as in consumer products, there is very broad potential exposure. Thus, there is known or potential exposure of workers involved in chlorobenzene production, processing, and use, and of the general population, both directly from consumer products and indirectly through the environment. For this reason and on the basis of limited toxic effects studies, EPA has proposed that certain chlorobenzenes be tested to assess their potential to cause chronic, reproductive, teratological, and oncogenic effects. Following resolution of methodology issues the Agency has raised, EPA will propose at a later date test rules for neurotoxic and mutagenic effects. Further, the Agency has decided not to propose test rules for acute toxicity and epidemiological studies.