Second-Generation Antidepressants for Treating Adult Depression: An Update. Clinician Research Summary.

摘要

As an update to a 2007 report, a systematic review of 248 clinical studies published between January 1980 and January 2011 examined the comparative effectiveness, benefits, and adverse effects of second-generation antidepressants for adults with depression. This review did not cover nonpharmaceutical treatments for depression, the comparative effectiveness of first-generation antidepressants, or the use of second-generation antidepressants in treating other axis 1 disorders including substance use disorders, bipolar disorder, bulimia nervosa, or schizophrenia. This summary is provided to inform discussions of options with patients and to assist in decisionmaking along with consideration of a patients values and preferences. Reviews of evidence should not be construed to represent clinical recommendations or guidelines.