Immune Injury in Occupational Respiratory Disease

摘要

Work on nine different research projects on immune injury in occupational respiratory disease falling under the grant is reviewed. Topics included the pulmonary activities of Thermoactinomyces vulgaris and Micropolyspora faeni; comparison of endotoxin/like properties of T. vulgaris and M. faeni with known enterobacterial lipopolysaccharides; inflammatory changes induced in the lung by inhalation of M. faeni spores, cotton dust, cotton bract dust, Escherichia coli, and purified endotoxin aerosols; the effects of inflammatory changes on respiratory immunization with soluble or particulate antigens; the role of APC activation by inflammatory agents; the local and systemic cell mediated immunocompetence of lymphoid cells from unimmunized experimental animals; a soluble and a particulate form of a protein antigen for aerosol immunization; appropriate immunization protocols to deliver soluble and particulate antigen to the lower respiratory tract; and the effect of local respiratory immunization with a soluble and particulate form of protein antigen on the induction of local and systemic cell mediated immunity.