Chronic Inhalation Toxicity of 1,2-Dibromoethane in Rats with and without Dietary Disulfiram (Revised Edition)

摘要

The effects of chronic exposure to 20 parts per million (ppm) 1,2-dibromoethane (106934) (EDB) were studied in Sprague-Dawley-rats. Male and female rats were exposed to EDB for 7 hours/day, 5 days/week for 18 months; some rats were also given a diet containing 0.05 percent disulfiram (97778). Administration of EDB with disulfiram resulted in most of the rats dying or being terminated during the first 12 months; all rats in the group died or were terminated by the fifteenth month. The group receiving EDB alone had higher mortality than a control group or a group receiving disulfiram alone. Body weight was depressed in the EDB/disulfiram group to a greater extent than in the EDB group. The EDB/disulfiram group showed a significant increase in the incidence of tumors of the liver and mesentery, compared to the group receiving EDB alone. EDB/disulfiram resulted in a tenfold increase in hepatocellular carcinoma, compared to EDB alone. Testicular atrophy was found in 88 percent of the EDB/disulfiram males, but in only 2 percent of EDB males.