Information Profiles on Potential Occupational Hazards: Trimethylbenzenes

摘要

Information on potential occupational hazards from hemimellitene (526738), pseudocumene (95636), and mesitylene (108678) was reviewed. Topics discussed included chemical and physical properties, production, use, manufacturers and distributors, manufacturing processes, occupational exposures and biological effects. Studies indicated that these compounds enter the body primarily through inhalation but can also be absorbed through the skin. Central nervous system depression, irritation of mucous membranes, and respiratory irritation have been caused by exposure to these chemicals in experimental animals. Pneumonitis, edema, tissue necrosis and hemorrhage of the lungs have been brought about by the aspiration of liquid trimethylbenzenes. The use of an organic solvent containing 50 percent pseudocumene, 30 percent mesitylene, and traces of hemimellitene caused hypochromic anemia, hemopoietic disturbances, chronic asthmatic bronchitis, and central nervous system depression in humans.